Are There Any Drugs That Affect Depo-Provera’s Effectiveness?

QUESTION:

Dear Dr. Heller,

Are there any drugs that affect Depo-Provera’s effectiveness?

 

ANSWER:

Depo-Provera is a long lasting contraceptive injection.  It generally lasts 3 months, and prevents the monthly mood swings many women experience.  Occasionally women feel ill on the medications. The only drug interaction is with “aminoglutethimide” – which will make the injection less effective.