QUESTION:
Dear Dr. Heller,
Very informative web site. I have a question about BuSpar. Is it possible that it can effect your estrogen levels? I am presently taking Sam-e (400mg) along with 10mg of BuSpar. I am experiencing painful breast tenderness (normally only usually happens pre-menstruation). Any information would be helpful.
Thanks.
ANSWER:
There’s nothing in the package insert (or PDR) about it, and I’ve never encountered a patient complaining of breast tenderness with BuSpar. There are concerns about Sam-e, particularly with drug interactions. That would be the more likely explanation, along with some other GYN problem unrelated to either medication.