CAN WELLBUTRIN (BUPROPRION) MAKE THE BPD WORSE? 
Ask The Doctor Dr. Leland Heller Biological Unhappiness 
CAN WELLBUTRIN (BUPROPRION) MAKE THE BPD WORSE? 
Question: Hello Dr. Heller. I have felt some type of acceleration in behavior in the past three weeks (as usual, wrong direction). My question is in regards to Wellbutrin (buproprion) – I have been taking 100mg/day ER since March 2006 and will quit taking it tomorrow as I now realize what it does to a probable person with the BPD. I believe the information on your site in regards to increased dopamine which of course Wellbutrin does. By the way, I’m not officially diagnosed (with BPD) but unofficially by my loving wife. Best of luck and God bless. Dr. Heller’s Answer: If an individual has the cognitive generalized anxiety disorder (GAD – genetic worry), Wellbutrin is likely to increase the anxiety until the GAD is treated first. Anything that worsens BPD anxiety will probably increase dysphoria (anxiety, rage, depression and despair) that is usually “self-treated” with self destructive behaviors like binge spending, binge eating, self mutilation, reckless driving, substance abuse, sexual indiscretions, etc. I don’t believe the Wellbutrin (buproprion) problem is due to dopamine, although your conclusion is logical. Once the BPD patient is stable, Wellbutrin can be a very effective “add-on” for sexual side effects or persistent “blahs”. 
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